Yup, you can substitute against the "reason" parameter of the below substitution documentation in field descriptions.
www.joomlapolis.com/documentation/279-community-builder/tutorials/18353-using-substitutions-throughout-cb
Examples as follows.
Profile Edit:
Code:
[cb:if reason="edit"]This displays in profile edit only.[/cb:if]
Userlist Search:
Code:
[cb:if reason="search"]This displays in userlist search only.[/cb:if]
You can have multiple of these in your description as well as use the [cb:else][/cb:else] usage. Example as follows.
Code:
[cb:if reason="search"]This displays in userlist search only.[cb:else]This displays everywhere else.[/cb:else][/cb:if]